Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 5/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 12/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033551 | 0.85 | EPHX2 (0.46) | EPHX2PPARGP2RX7KLKB1 | |
| SCHEMBL1031357 | 0.80 | P2RX7 (0.46) | EPHX2PPARGP2RX7 | |
| SCHEMBL1032399 | 0.80 | WDR5 (0.46) | EPHX2PPARGKMT2A | |
| SCHEMBL1031826 | 0.78 | PTGER4 (0.43) | PPARGP2RX7KMT2AKLKB1 | |
| SCHEMBL1029462 | 0.76 | ALDH1A1 (0.46) | EPHX2 | |
| SCHEMBL4116626 | 0.76 | CNR1 (0.42) | MEN1KMT2A | |
| SCHEMBL1028564 | 0.74 | ALDH1A1 (0.38) | EPHX2P2RX7MEN1KMT2A | |
| SCHEMBL1031997 | 0.73 | TAAR1 (0.45) | EPHX2MEN1KMT2A | |
| SCHEMBL1032390 | 0.72 | P2RX7 (0.42) | EPHX2PPARGP2RX7 | |
| SCHEMBL1030436 | 0.72 | S1PR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |
| EP-2035375-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007141039-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-13 | — | — | WO | disclosed |