Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032390 | 0.85 | P2RX7 (0.42) | P2RX7NTRK1EPHX2PPARG | |
| SCHEMBL1030468 | 0.83 | P2RX7 (0.48) | P2RX7NTRK1EPHX2PPARG | |
| SCHEMBL1032752 | 0.81 | EPHX1 (0.40) | — | |
| SCHEMBL1032699 | 0.80 | EPHX2 (0.42) | P2RX7EPHX2PPARG | |
| SCHEMBL1030010 | 0.76 | MAPK14 (0.50) | PPARG | |
| SCHEMBL1031886 | 0.73 | METAP2 (0.37) | — | |
| SCHEMBL1031826 | 0.72 | PTGER4 (0.43) | P2RX7PPARG | |
| SCHEMBL1033134 | 0.71 | P2RX7 (0.43) | P2RX7NTRK1EPHX2PPARG | |
| SCHEMBL1032701 | 0.71 | ALDH1A1 (0.44) | — | |
| SCHEMBL1030941 | 0.70 | TP53 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |