SCHEMBL10327373 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	2/20	0.46

▸	THRB	P10828	1/20	0.45

▸	KMT2A	Q03164	1/20	0.44

▸	AKT1	P31749	1/20	0.44

▸	TRPV4	Q9HBA0	11/20	0.43

▸	EPHX2	P34913	1/20	0.42

▸	CASR	P41180	1/20	0.42

▸	RAF1	P04049	2/20	0.41

▸	BRAF	P15056	2/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10327385	0.89	LMNA (0.46)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL10327267	0.86	LMNA (0.46)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL10327319	0.85	RAF1 (0.45)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL12946845	0.81	TRPV4 (0.44)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL12946857	0.81	TRPV4 (0.44)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL10327259	0.80	TRPV4 (0.49)	LMNAKMT2ATRPV4EPHX2CASR
SCHEMBL12946985	0.80	MAPK8 (0.45)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL10180583	0.77	TRPV4 (0.42)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL10180493	0.77	TRPV4 (0.42)	LMNATHRBKMT2AAKT1TRPV4
SCHEMBL10180028	0.76	MAPK8 (0.45)	LMNATHRBKMT2AAKT1TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1678168-B1	P70S6 KINASE MODULATORS AND METHOD OF USE	EXELIXIS INC (US)	2012-07-11	—	—	EP	disclosed