⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765173 | 0.71 | MAOA (0.32) | — | |
| SCHEMBL16436876 | 0.64 | SRD5A2 (0.46) | — | |
| SCHEMBL6544012 | 0.62 | GABRP (0.33) | — | |
| SCHEMBL18137236 | 0.61 | ITGB3 (0.39) | — | |
| SCHEMBL20313438 | 0.61 | CA12 (0.36) | — | |
| SCHEMBL18381117 | 0.60 | ABAT (0.32) | — | |
| SCHEMBL14026253 | 0.60 | ABAT (0.32) | — | |
| SCHEMBL13589752 | 0.60 | — | — | |
| SCHEMBL13140760 | 0.59 | TSHR (0.39) | — | |
| SCHEMBL11307657 | 0.59 | ABAT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200360392-A1 | DIGALLIC ACID FOR REDUCTION OF INFLAMMATORY CYTOKINE ACTIVITY | ENZO BIOCHEM, INC (US) | 2020-11-19 | — | — | US | disclosed |
| US-20190350936-A1 | METHOD FOR PROMOTING WOUND HEALING BY ADMINISTERING A COMPOUND WHICH BINDS LDL-RECEPTOR-RELATED PROTEIN (LRP) LIGAND BINDING DOMAIN | ENZO BIOCHEM, INC. (US) | 2019-11-21 | — | — | US | disclosed |
| US-20170020883-A1 | METHOD FOR PROMOTING WOUND HEALING BY ADMINISTERING A COMPOUND WHICH BINDS LDL-RECEPTOR-RELATED PROTEIN (LRP) LIGAND BINDING DOMAIN | ENZO BIOCHEM, INC. (US) | 2017-01-26 | — | — | US | disclosed |
| US-20170020883-A1 | METHOD FOR PROMOTING WOUND HEALING BY ADMINISTERING A COMPOUND WHICH BINDS LDL-RECEPTOR-RELATED PROTEIN (LRP) LIGAND BINDING DOMAIN | ENZO BIOCHEM, INC. (US) | 2017-01-26 | — | — | US | disclosed |
| US-9492419-B2 | Method for treating crohn'S disease or ulcerative colitis by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain | ENZO BIOCHEM, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492419-B2 | Method for treating crohn'S disease or ulcerative colitis by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain | ENZO BIOCHEM, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20150216832-A1 | METHOD FOR TREATING INFLAMMATION BY ADMINISTERING A COMPOUND WHICH BINDS LDL-RECEPTOR-RELATED PROTEIN (LRP) LIGAND BINDING DOMAIN | ENZO BIOCHEM, INC. (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150216832-A1 | METHOD FOR TREATING INFLAMMATION BY ADMINISTERING A COMPOUND WHICH BINDS LDL-RECEPTOR-RELATED PROTEIN (LRP) LIGAND BINDING DOMAIN | ENZO BIOCHEM, INC. (US) | 2015-08-06 | — | — | US | disclosed |
| US-9046537-B2 | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain | ENZO BIOCHEM, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-9046537-B2 | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain | ENZO BIOCHEM, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-20120184616-A9 | Methods for treating inflammation | ENZO LIFE SCIENCES, INC. | 2012-07-19 | — | — | US | disclosed |
| US-20120184616-A9 | Methods for treating inflammation | ENZO LIFE SCIENCES, INC. | 2012-07-19 | — | — | US | disclosed |
| US-20110105606-A1 | Compositions and methods affecting the signaling pathways of LRP receptors | RABBANI ELAZAR | 2011-05-05 | — | — | US | disclosed |
| US-20110105606-A1 | Compositions and methods affecting the signaling pathways of LRP receptors | RABBANI ELAZAR | 2011-05-05 | — | — | US | disclosed |
| WO-2010017472-A1 | COMPOSITIONS AND METHODS AFFECTING THE SIGNALING PATHWAYS OF LRP RECEPTORS | ENZO BIOCHEM, INC. (US) | 2010-02-11 | — | — | WO | disclosed |