SCHEMBL1032858

SCHEMBL1032858

Ic1cccc(-c2ccccc2-c2cccc(I)c2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 1/20 0.44
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
APP P05067 2/20 0.41
PDE4A P27815 2/20 0.40
GALR1 P47211 1/20 0.38
IDO1 P14902 2/20 0.35
BACE1 P56817 1/20 0.35
FAAH O00519 1/20 0.34
MGLL Q99685 1/20 0.34
ABCG2 Q9UNQ0 1/20 0.34
ALDH1A1 P00352 4/20 0.33
HSD17B10 Q99714 2/20 0.33
HPGD P15428 1/20 0.33
BCL2L1 Q07817 1/20 0.33
ABL1 P00519 1/20 0.33
ABCB1 P08183 1/20 0.33
BCR P11274 1/20 0.33
CYP2A6 P11509 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19607480 0.95 BACE1 (0.42) METAP2CHRNB4CHRNA3APPPDE4A
SCHEMBL7714897 0.93 BACE1 (0.41) METAP2CHRNB4CHRNA3APPPDE4A
SCHEMBL6003070 0.88 METAP2 (0.44) METAP2CHRNB4CHRNA3APPPDE4A
SCHEMBL22589222 0.87 RAB9A (0.42) METAP2IDO1ALDH1A1HPGD
SCHEMBL19791267 0.87 ENPP3 (0.45) ALDH1A1HSD17B10HPGDABL1
SCHEMBL21149112 0.85 HPRT1 (0.40) METAP2CHRNB4CHRNA3APPALDH1A1
SCHEMBL24658105 0.84 PDE4A (0.38) METAP2CHRNB4CHRNA3PDE4AGALR1
SCHEMBL21149111 0.84 METAP2 (0.42) METAP2CHRNB4CHRNA3APPPDE4A
SCHEMBL8423789 0.84 HPGD (0.58) APPBACE1ALDH1A1HSD17B10HPGD
SCHEMBL23174276 0.84 ALDH1A1 (0.58) METAP2CHRNB4CHRNA3PDE4AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4714779-A Aromatic aryl amine polymers XEROX CORPORATION (US) 1987-12-22 US claimed
EP-0052961-B1 AMINE POLYMERS AND IMAGING MEMBERS CONTAINING AMINE POLYMERS XEROX CORPORATION (US) 1985-09-11 EP claimed
EP-0052961-A1 Amine polymers and imaging members containing amine polymers XEROX CORPORATION (US) 1982-06-02 EP claimed
WO-2021150048-A1 ORGANIC LIGHT-EMITTING DEVICE 주식회사 엘지화학 2021-07-29 WO disclosed
WO-2020226280-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME 주식회사 엘지화학 2020-11-12 WO disclosed
EP-1850185-B1 Imaging member, method of imaging using it and method of making said imaging member XEROX CORP (US) 2011-01-19 EP disclosed
EP-1850185-A2 Imaging Member Xerox Corporation (US) 2007-10-31 EP disclosed
US-4764625-A POTASSIUM HYDROXIDE, COPPER CATALYST XEROX CORPORATION (US) 1988-08-16 US disclosed
US-4714779-A Aromatic aryl amine polymers XEROX CORPORATION (US) 1987-12-22 US disclosed
EP-0052961-B1 AMINE POLYMERS AND IMAGING MEMBERS CONTAINING AMINE POLYMERS XEROX CORPORATION (US) 1985-09-11 EP disclosed
EP-0034425-B1 PROCESS FOR PREPARING ARYLAMINES XEROX CORPORATION (US) 1984-05-16 EP disclosed
EP-0028888-B1 PROCESS FOR PRODUCING A DIIODINATED POLYARYLIDENE COMPOUND XEROX CORPORATION (US) 1984-04-25 EP disclosed
EP-0029703-B1 ELECTROPHOTOGRAPHIC IMAGING MEMBER XEROX CORPORATION (US) 1984-03-21 EP disclosed
EP-0052961-A1 Amine polymers and imaging members containing amine polymers XEROX CORPORATION (US) 1982-06-02 EP disclosed
EP-0034425-A2 Process for preparing arylamines XEROX CORPORATION (US) 1981-08-26 EP disclosed
US-4273846-A Imaging member having a charge transport layer of a terphenyl diamine and a polycarbonate resin XEROX CORPORATION (US) 1981-06-16 US disclosed
EP-0028888-A1 Process for producing a diiodinated polyarylidene compound XEROX CORPORATION (US) 1981-05-20 EP disclosed
US-4240987-A Chemical process XEROX CORPORATION (US) 1980-12-23 US disclosed