Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.60 |
| ▸ | AGPAT2 | O15120 | 7/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 5/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734845 | 0.85 | CDK9 (0.63) | PIK3CAPIK3CBPIK3CGCDK2CDK9 | |
| SCHEMBL14088787 | 0.79 | JAK2 (0.59) | PIK3CAPIK3CBPIK3CGCDK2JAK2 | |
| SCHEMBL3614861 | 0.78 | ABL1 (0.61) | PIK3CAPIK3CBPIK3CGCDK2JAK2 | |
| SCHEMBL1033197 | 0.77 | ALDH1A1 (0.55) | AGPAT2JAK2 | |
| SCHEMBL4737275 | 0.77 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGCDK2CDK9 | |
| SCHEMBL1034516 | 0.76 | SMN1; SMN2 (0.60) | AGPAT2CDK2JAK2GSK3BMAP4K4 | |
| SCHEMBL12275494 | 0.76 | PLK1 (0.70) | PIK3CAPIK3CBPIK3CGCDK2JAK2 | |
| SCHEMBL14651244 | 0.76 | PLK1 (0.58) | PIK3CAPIK3CBPIK3CGCDK2EGFR | |
| SCHEMBL8253883 | 0.76 | ZAP70 (0.68) | PIK3CAPIK3CBPIK3CGCDK2JAK2 | |
| SCHEMBL12764230 | 0.76 | PRKCA (0.56) | PIK3CAPIK3CBPIK3CGCDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | claimed |
| WO-2011008931-A2 | ARYLPYRIMIDINE COMPOUNDS AND COMBINATION THERAPY COMPRISING SAME FOR TREATING CYSTIC FIBROSIS & RELATED DISORDERS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |