Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RHEB | Q15382 | 4/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333347 | 0.84 | NPBWR1 (0.41) | NPC1RAB9AMEN1KMT2AAMY1A | |
| SCHEMBL10333237 | 0.77 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL10845991 | 0.73 | PDE5A (0.41) | NPC1RAB9AHTTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10845995 | 0.72 | PDE5A (0.42) | NPC1RAB9AHTTKDM4EALDH1A1 | |
| SCHEMBL9702847 | 0.71 | PDE4A (0.42) | NPC1RAB9AAMY1AATMERAP1 | |
| SCHEMBL10333320 | 0.71 | NPC1 (0.59) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL15876215 | 0.70 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL22955432 | 0.69 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL3090064 | 0.69 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL18890560 | 0.69 | RHEB (0.51) | NPC1RAB9AMEN1KMT2ARHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | disclosed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |