Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.61 |
| ▸ | RAB9A | P51151 | 12/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | HPGD | P15428 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10613291 | 0.84 | RAB9A (0.51) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10987330 | 0.82 | ALDH1A1 (0.58) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10845991 | 0.80 | PDE5A (0.41) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10333347 | 0.79 | NPBWR1 (0.41) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28564047 | 0.79 | HPGD (0.59) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL10845995 | 0.79 | PDE5A (0.42) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28662646 | 0.77 | ALDH1A1 (0.58) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10333321 | 0.77 | NPC1 (0.52) | NPC1RAB9AALDH1A1HTTKDM4E | |
| SCHEMBL227743 | 0.77 | NPC1 (0.78) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3170855 | 0.76 | NPC1 (1.00) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |