Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | IDE | P14735 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | HLCS | P50747 | 6/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL3790437 | 0.98 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL693036 | 0.98 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011738 | 0.91 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011736 | 0.91 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770769 | 0.89 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770770 | 0.88 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL3425472 | 0.88 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL739967 | 0.88 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL20473405 | 0.88 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL16653090 | 0.87 | TDP1 (0.83) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852004-B1 | MULTIPLEXED ANALYSIS OF CLINICAL SPECIMENS | LUMINEX CORP (US) | 2011-01-19 | — | — | EP | disclosed |
| US-20040059519-A1 | Multiplexed analysis of clinical specimens apparatus and methods | LUMINEX CORPORATION | 2004-03-25 | — | — | US | disclosed |
| US-6449562-B1 | Multiplexed analysis of clinical specimens apparatus and method | LUMINEX CORPORATION | 2002-09-10 | — | — | US | disclosed |
| WO-1999036564-A9 | MULTIPLEXED ANALYSIS OF CLINICAL SPECIMENS APPARATUS AND METHODS | LUMINEX CORP (US) | 1999-10-28 | — | — | WO | disclosed |
| WO-1999036564-A1 | MULTIPLEXED ANALYSIS OF CLINICAL SPECIMENS APPARATUS AND METHODS | LUMINEX CORPORATION (US) | 1999-07-22 | — | — | WO | disclosed |
| EP-0852004-A2 | MULTIPLEXED ANALYSIS OF CLINICAL SPECIMENS | LUMINEX CORP (US) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997014028-A9 | MULTIPLEXED ANALYSIS OF CLINICAL SPECIMENS APPARATUS AND METHOD | — | 1997-08-21 | — | — | WO | disclosed |
| WO-1997014028-A2 | MULTIPLEXED ANALYSIS OF CLINICAL SPECIMENS APPARATUS AND METHOD | LUMINEX CORPORATION (US) | 1997-04-17 | — | — | WO | disclosed |