Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | IDE | P14735 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | HLCS | P50747 | 6/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL3790437 | 1.00 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL1033634 | 0.98 | TDP1 (0.69) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011738 | 0.92 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011736 | 0.92 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770769 | 0.91 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770770 | 0.90 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL3425472 | 0.90 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL739967 | 0.90 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL16653090 | 0.89 | TDP1 (0.83) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL6865574 | 0.89 | TDP1 (0.87) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062820-A | Method for producing biotin, and L-lysine salt of biotin and method for producing same | 株式会社德山 | 2023-11-14 | — | — | CN | claimed |
| WO-2022202982-A1 | METHOD FOR PREPARING BIOTIN, L-LYSINE SALT OF BIOTIN, AND METHOD FOR PREPARING SAME | 株式会社トクヤマ | 2022-09-29 | — | — | WO | claimed |
| CN-103513026-B | Signal amplification type immunofluorescence probe, and preparation method and application thereof | WU JIAN | 2015-04-29 | — | — | CN | claimed |
| CN-103513026-A | Signal amplification type immunofluorescence probe, and preparation method and application thereof | WU JIAN | 2014-01-15 | — | — | CN | claimed |
| CN-102565383-A | Signal amplification type immunofluorescence probe and preparation method and application thereof | JIAN WU | 2012-07-11 | — | — | CN | claimed |
| CN-117062820-A | Method for producing biotin, and L-lysine salt of biotin and method for producing same | 株式会社德山 | 2023-11-14 | — | — | CN | disclosed |
| CN-116121294-A | Increasing vegetable oil content by altering negative regulatory factors of acetyl-COA carboxylase | 密苏里大学管理者 | 2023-05-16 | — | — | CN | disclosed |
| WO-2022202982-A1 | METHOD FOR PREPARING BIOTIN, L-LYSINE SALT OF BIOTIN, AND METHOD FOR PREPARING SAME | 株式会社トクヤマ | 2022-09-29 | — | — | WO | disclosed |
| CN-114980906-A | Compositions and methods for increasing cell viability and longevity and reducing molecular aging | JUVN3控股有限责任公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-107405377-B | Method for disrupting exosome, exosome disruption kit, and method for separating exosome from normal cell | 三井化学株式会社 | 2021-08-06 | — | — | CN | disclosed |
| EP-3287137-B1 | METHOD FOR DISRUPTING EXOSOMES, EXOSOME DISRUPTION KIT, AND METHOD FOR SEPARATING EXOSOMES DERIVED FROM NORMAL CELLS | MITSUI CHEMICALS INC (JP) | 2021-05-05 | — | — | EP | disclosed |
| CN-112179883-A | Active fluorescence detection method of humanized silent information regulatory factor 4 | 贵州医科大学 | 2021-01-05 | — | — | CN | disclosed |
| EP-0743956-A1 | PRETARGETING METHODS AND COMPOUNDS | NeoRx (US) | 1996-11-27 | — | — | EP | disclosed |
| EP-0736035-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1996-10-09 | — | — | EP | disclosed |
| EP-0732943-A1 | THREE-STEP PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| EP-0683676-A1 | DIRECTED BIODISTRIBUTION OF SMALL MOLECULES | NEORX CORPORATION (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1995015770-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |
| WO-1995015335-A2 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-08 | — | — | WO | disclosed |
| WO-1995014493-A1 | THREE-STEP PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-01 | — | — | WO | disclosed |
| WO-1994017829-A1 | DIRECTED BIODISTRIBUTION OF SMALL MOLECULES | NEORX CORPORATION (US) | 1994-08-18 | — | — | WO | disclosed |