Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | IDE | P14735 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | HLCS | P50747 | 6/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL693036 | 1.00 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL1033634 | 0.98 | TDP1 (0.69) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011738 | 0.92 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011736 | 0.92 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770769 | 0.91 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770770 | 0.90 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL3425472 | 0.90 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL739967 | 0.90 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL16653090 | 0.89 | TDP1 (0.83) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL6865574 | 0.89 | TDP1 (0.87) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260063634-A1 | BIOCHEMICAL PROBES ATTACHED TO EPOXY-BASED RESINS | IDEXX LAB INC (US) | 2026-03-05 | — | — | US | disclosed |
| CN-121058800-A | Lactating sow feed for improving lactation yield of sows and preparation method thereof | 赣州朱师傅预混饲料事业有限公司 | 2025-12-05 | — | — | CN | disclosed |
| US-12487239-B2 | Biochemical probes attached to epoxy-based resins | IDEXX LABORATORIES, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20250002970-A1 | AMPLIFIABLE METABOLIC LABELING FOR DETECTION OF BACTERIAL VIABILITY, GROWTH AND ANTIBIOTIC SUSCEPTIBILITY | UNIVERSITY OF MASSACHUSETTS | 2025-01-02 | — | — | US | disclosed |
| US-20240042063-A1 | LINKED AND OTHER pH-TRIGGERED COMPOUNDS | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES | 2024-02-08 | — | — | US | disclosed |
| EP-4302087-A1 | BIOCHEMICAL PROBES ATTACHED TO EPOXY-BASED RESINS | IDEXX Laboratories, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| CN-116981944-A | Biochemical probe connected to epoxy resin | 艾德克斯实验室公司 | 2023-10-31 | — | — | CN | disclosed |
| US-11802878-B2 | Protein sequencing method and reagents | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2023-10-31 | — | — | US | disclosed |
| EP-4264246-A1 | METHOD FOR MANUFACTURING PROTEIN BIOELECTRONIC DEVICES | Arizona Board of Regents on behalf of Arizona State University (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-116121294-A | Increasing vegetable oil content by altering negative regulatory factors of acetyl-COA carboxylase | 密苏里大学管理者 | 2023-05-16 | — | — | CN | disclosed |
| EP-3341379-A1 | INHIBITORS OF EZH2 | Eli Lilly and Company (US) | 2018-07-04 | — | — | EP | disclosed |
| US-20180055906-A1 | METHOD FOR DESTROYING EXOSOMES, KIT FOR DESTROYING EXOSOMES, AND METHOD FOR ISOLATING EXOSOMES DERIVED FROM NORMAL CELLS | MITSUI CHEMICALS, INC. (JP) | 2018-03-01 | — | — | US | disclosed |
| EP-3287137-A1 | METHOD FOR DISRUPTING EXOSOMES, EXOSOME DISRUPTION KIT, AND METHOD FOR SEPARATING EXOSOMES DERIVED FROM NORMAL CELLS | Mitsui Chemicals, Inc. (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-9718838-B2 | Inhibitors of EZH2 | ELI LILLY AND COMPANY (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170066780-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY | 2017-03-09 | — | — | US | disclosed |
| WO-2017035060-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY (US) | 2017-03-02 | — | — | WO | disclosed |
| US-9527837-B2 | Inhibitors of EZH2 | ELI LILLY AND COMPANY (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160159782-A1 | INHIBITORS OF EZH2 | LILLY CO ELI (US) | 2016-06-09 | — | — | US | disclosed |
| WO-2016089804-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2010018413-A2 | DETECTION METHOD | ISIS INNOVATION LIMITED (GB) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240042063-A1 | LINKED AND OTHER pH-TRIGGERED COMPOUNDS | LIPA, PHOSPHO1, NGLY1 | TDP1 3953/4885MEN1 79/4885ABL1 1414/4885 |
| US-20260063634-A1 | BIOCHEMICAL PROBES ATTACHED TO EPOXY-BASED RESINS | CAD, FGB, S100B | TDP1 839/4885MEN1 3478/4885ABL1 2875/4885 |
| US-20160159782-A1 | INHIBITORS OF EZH2 | EZH2, BMI1, EZH1 | TDP1 3235/4885MEN1 994/4885ABL1 106/4885 |
| US-20170066780-A1 | INHIBITORS OF EZH2 | EZH2, BMI1, EZH1 | TDP1 3463/4885MEN1 1129/4885ABL1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.