Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28804419 | 0.81 | HSD17B10 (0.44) | ALDH1A1GABRA1GABRB2KDM4EGAA | |
| SCHEMBL7749583 | 0.78 | GABRA1 (0.41) | ALDH1A1GABRA1GABRB2KDM4EGAA | |
| SCHEMBL728402 | 0.76 | KMT2A (0.47) | ALDH1A1GABRA1GABRB2KDM4ECYP3A4 | |
| SCHEMBL8724008 | 0.75 | ALDH1A1 (0.43) | ALDH1A1GABRA1GABRB2KDM4ECYP3A4 | |
| SCHEMBL16241709 | 0.74 | CYP1A2 (0.52) | ALDH1A1PPARGPPARDPPARARXRA | |
| SCHEMBL729571 | 0.73 | ALDH1A1 (0.47) | ALDH1A1GABRA1GABRB2KDM4ECYP3A4 | |
| SCHEMBL27930641 | 0.72 | ALDH1A1 (0.55) | ALDH1A1GABRA1GABRB2KDM4ECYP3A4 | |
| SCHEMBL5748760 | 0.72 | IDO1 (0.50) | ALDH1A1PPARGPPARDPPARARXRA | |
| SCHEMBL28831011 | 0.72 | ALDH1A1 (0.45) | ALDH1A1GABRA1GABRB2KDM4ECYP3A4 | |
| SCHEMBL4338851 | 0.72 | MEN1 (0.37) | ALDH1A1GABRA1GABRB2KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365539-A4 | HUMAN LEUCOCYTE ELASTASE INHIBITOR COMPOUNDS | — | 1990-12-05 | — | — | EP | disclosed |
| EP-0365539-A1 | HUMAN LEUCOCYTE ELASTASE INHIBITOR COMPOUNDS | AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) | 1990-05-02 | — | — | EP | disclosed |
| WO-1988010258-A1 | HUMAN LEUCOCYTE ELASTASE INHIBITOR COMPOUNDS | LA TROBE UNIVERSITY (AU) | 1988-12-29 | — | — | WO | disclosed |