Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 8/20 | 0.52 |
| ▸ | FAAH | O00519 | 4/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24938802 | 0.82 | HCAR2 (0.49) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL14678413 | 0.80 | MGLL (0.77) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL145737 | 0.80 | MGLL (0.77) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL756295 | 0.78 | AKR1B1 (0.43) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL15391717 | 0.74 | PTGS1 (0.70) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL34464 | 0.74 | PTGS1 (0.70) | MGLLFAAHPTGS1PTGS2TP53 | |
| N-Ethylmaleimide SCHEMBL28290806 | 0.74 | MGLL (0.59) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL515800 | 0.73 | PTGS1 (0.52) | MGLLFAAHPTGS1PTGS2TP53 | |
| SCHEMBL28981238 | 0.73 | PTGS1 (0.68) | MGLLFAAHPTGS1PTGS2TP53 | |
| Hydrochloric Acid SCHEMBL25414956 | 0.73 | PTGS1 (0.68) | MGLLFAAHPTGS1PTGS2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2140225-A | — | — | None | — | — | JP | disclosed |
| JP-H02140225-A | EPOXY RESIN MOLDING MATERIAL COMPOSITION | MATSUSHITA ELECTRIC WORKS LTD | 1990-05-29 | — | — | JP | disclosed |