Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340259 | 0.80 | MTNR1A (0.57) | MTNR1AMTNR1BHTR1AHTR2A | |
| SCHEMBL23248790 | 0.77 | MEN1 (0.40) | — | |
| SCHEMBL10340613 | 0.75 | MAOA (0.48) | MAOAMTNR1AMTNR1BHTR1A | |
| SCHEMBL10682096 | 0.69 | — | — | |
| SCHEMBL6996649 | 0.61 | CYP3A4 (0.39) | HTR1AHTR2A | |
| SCHEMBL13701016 | 0.60 | MCL1 (0.41) | MAOAMTNR1AMTNR1B | |
| Hyrtioreticulin D SCHEMBL30434518 | 0.59 | HTR2A (0.39) | MAOAMTNR1AMTNR1BHTR1AHTR2A | |
| SCHEMBL23261875 | 0.57 | MAP3K14 (0.39) | MAOAMTNR1AMTNR1BHTR1A | |
| SCHEMBL23261947 | 0.57 | DRD2 (0.38) | MAOAMTNR1AMTNR1BHTR1AHTR2A | |
| SCHEMBL4420013 | 0.57 | HTR2C (0.39) | MAOAHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | claimed |
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |