Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10340260 | 0.93 | MAOA (0.43) | MAOAFYNMTNR1AMTNR1BDRD2 | |
| SCHEMBL23261947 | 0.81 | DRD2 (0.38) | MAOAMTNR1AMTNR1BDRD2DRD3 | |
| SCHEMBL23261875 | 0.81 | MAP3K14 (0.39) | MAOAMTNR1AMTNR1BDRD2HTR1A | |
| SCHEMBL8891546 | 0.79 | HTR1A (0.47) | MTNR1AMTNR1BDRD2HTR1AHSD17B10 | |
| SCHEMBL7514066 | 0.79 | HTR1A (0.47) | MTNR1AMTNR1BDRD2HTR1A | |
| SCHEMBL10347197 | 0.78 | HTR1D (0.38) | MAOAMTNR1AMTNR1BHTR1A | |
| Hydrochloric Acid SCHEMBL7515525 | 0.78 | HTR1A (0.46) | MTNR1AMTNR1BDRD2HTR1A | |
| SCHEMBL8892925 | 0.78 | HTR1A (0.41) | MAOAMTNR1AMTNR1BHTR1A | |
| SCHEMBL9503999 | 0.77 | MTNR1A (0.60) | MTNR1AMTNR1BDRD2DRD3 | |
| SCHEMBL10340392 | 0.77 | MTNR1A (0.50) | MAOAMTNR1AMTNR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | claimed |
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |