Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340210 | 0.89 | MAPT (0.71) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL8639229 | 0.89 | MAPT (0.71) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL27546664 | 0.86 | NPC1 (0.60) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL10340313 | 0.86 | ALDH1A1 (0.65) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL14075300 | 0.85 | KDM4E (0.78) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL29396023 | 0.84 | MAPT (0.62) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL22191541 | 0.84 | MAPT (0.62) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL5595072 | 0.84 | CFD (0.62) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL10340244 | 0.82 | MAPK8 (0.62) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL10844635 | 0.81 | KMT2A (0.66) | KDM4EALDH1A1HSD17B10MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169537-B1 | 2-PHENYLALKYL-3-AMINOALKYL-4(3H)-QUINAZOLINONES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS AND USE | MITSUBISHI KASEI CORPORATION (JP) | 1990-01-03 | — | — | EP | disclosed |
| US-4668682-A | CALCIUM ANTAGONISTS, VASODILATORS, HYPOTENSIVE AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0169537-A2 | 2-Phenylalkyl-3-aminoalkyl-4(3H)-quinazolinones, processes for preparing them, pharmaceutical compositions and use | MITSUBISHI KASEI CORPORATION (JP) | 1986-01-29 | — | — | EP | disclosed |