Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639959 | 0.90 | KDM4E (0.60) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL10340271 | 0.86 | KDM4E (0.77) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL10340254 | 0.86 | KDM4E (0.63) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL15643259 | 0.84 | KMT2A (0.59) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL10340147 | 0.84 | ALDH1A1 (0.60) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL6183697 | 0.83 | HIF1A (0.69) | ALDH1A1HSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19427716 | 0.83 | KMT2A (0.69) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL19427444 | 0.82 | ALDH1A1 (0.73) | ALDH1A1HSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10340324 | 0.82 | TP53 (0.52) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL28618230 | 0.80 | CHEK1 (0.63) | ALDH1A1KDM4EHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169537-B1 | 2-PHENYLALKYL-3-AMINOALKYL-4(3H)-QUINAZOLINONES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS AND USE | MITSUBISHI KASEI CORPORATION (JP) | 1990-01-03 | — | — | EP | disclosed |
| US-4668682-A | CALCIUM ANTAGONISTS, VASODILATORS, HYPOTENSIVE AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0169537-A2 | 2-Phenylalkyl-3-aminoalkyl-4(3H)-quinazolinones, processes for preparing them, pharmaceutical compositions and use | MITSUBISHI KASEI CORPORATION (JP) | 1986-01-29 | — | — | EP | disclosed |