Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532979 | 0.90 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL11022976 | 0.85 | MTNR1A (0.61) | MTNR1AMTNR1BHTR1DHTR1B | |
| SCHEMBL11036691 | 0.85 | MTNR1A (0.71) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL9531900 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BDRD2 | |
| SCHEMBL10340214 | 0.82 | MTNR1A (0.47) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL10340217 | 0.81 | MTNR1A (0.69) | MTNR1AMTNR1BHTR1DHTR1B | |
| SCHEMBL9537304 | 0.80 | MTNR1A (0.58) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL9537025 | 0.80 | MTNR1A (0.58) | MTNR1AMTNR1BHTR1DHTR1B | |
| SCHEMBL8409987 | 0.80 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL10340399 | 0.80 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |