SCHEMBL8409987

SCHEMBL8409987

COc1ccc2[nH]cc3c2c1CC(NC(C)=O)C3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 6/20 1.00
MTNR1B P49286 6/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10340372 0.85 MTNR1A (0.74) MTNR1AMTNR1B
SCHEMBL6075588 0.84 MTNR1A (0.72) MTNR1AMTNR1B
SCHEMBL11036691 0.83 MTNR1A (0.71) MTNR1AMTNR1B
SCHEMBL6076480 0.82 MTNR1A (0.70) MTNR1AMTNR1B
SCHEMBL6077100 0.82 MTNR1A (0.70) MTNR1AMTNR1B
SCHEMBL6075567 0.82 MTNR1A (0.70) MTNR1AMTNR1B
SCHEMBL10340217 0.81 MTNR1A (0.69) MTNR1AMTNR1B
SCHEMBL8409830 0.81 MTNR1A (0.69) MTNR1AMTNR1B
SCHEMBL8409849 0.80 MTNR1A (0.66) MTNR1AMTNR1B
SCHEMBL10340388 0.80 MTNR1A (0.67) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737670-B1 Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them ADIR (FR) 1999-07-21 EP disclosed
EP-0737670-A1 Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1996-10-16 EP disclosed
EP-0162695-B1 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES SMITHKLINE BEECHAM CORPORATION (US) 1990-01-17 EP disclosed
EP-0162695-A1 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines SMITHKLINE BEECHAM CORPORATION (US) 1985-11-27 EP disclosed