Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532235 | 0.89 | MTNR1A (0.53) | MTNR1AMTNR1BDRD2GRIN2B | |
| SCHEMBL10340388 | 0.84 | MTNR1A (0.67) | MTNR1AMTNR1BDRD2 | |
| SCHEMBL9532979 | 0.82 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2 | |
| SCHEMBL10340399 | 0.82 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2 | |
| SCHEMBL10340393 | 0.82 | FYN (0.56) | MTNR1AMTNR1BDRD2GRIN2BFYN | |
| SCHEMBL11022976 | 0.81 | MTNR1A (0.61) | MTNR1AMTNR1B | |
| SCHEMBL11036691 | 0.80 | MTNR1A (0.71) | MTNR1AMTNR1BDRD2 | |
| Hydrochloric Acid SCHEMBL10447152 | 0.80 | DRD2 (0.61) | DRD2GRIN2BFYNBCHEACHE | |
| SCHEMBL10340372 | 0.78 | MTNR1A (0.74) | MTNR1AMTNR1B | |
| SCHEMBL10340261 | 0.77 | MTNR1A (0.49) | MTNR1AMTNR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332968-B1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |
| US-5021438-A | Having affinity for 5-hydroxytryptamine receptors; treating central nervous system and cardiovascular disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0332968-A1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1989-09-20 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |