Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.60 |
| ▸ | F7 | P08709 | 1/20 | 0.55 |
| ▸ | F3 | P13726 | 1/20 | 0.55 |
| ▸ | HPN | P05981 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.50 |
| ▸ | C1R | P00736 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385483 | 0.87 | F7 (0.49) | ELANEF7F3HPNNPC1 | |
| SCHEMBL5380224 | 0.86 | NPC1 (0.49) | ELANEF7F3HPNNPC1 | |
| SCHEMBL5385451 | 0.85 | HPN (0.52) | ELANEF7F3HPNNPC1 | |
| SCHEMBL11817024 | 0.84 | ELANE (0.71) | ELANEF7F3NPC1RAB9A | |
| SCHEMBL914467 | 0.84 | C1R (0.67) | ELANEF7F3C1RF2 | |
| SCHEMBL5382664 | 0.83 | ELANE (0.57) | ELANEHPNNPC1RAB9AC1R | |
| SCHEMBL10344443 | 0.83 | ELANE (0.66) | ELANEF7F3NPC1RAB9A | |
| SCHEMBL10741223 | 0.83 | HPN (0.61) | ELANEF7F3HPNNPC1 | |
| SCHEMBL14462682 | 0.82 | F7 (0.45) | ELANEF7F3HPNNPC1 | |
| SCHEMBL914657 | 0.82 | F7 (0.81) | ELANEF7F3HPNC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776853-B2 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| US-6656934-B2 | Enzyme inhibitor | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-12-02 | — | — | US | disclosed |