SCHEMBL5385451

SCHEMBL5385451

O=c1oc(-c2cccc(C(F)(F)F)c2)nc2ccc(-c3ccccc3)cc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPN P05981 1/20 0.52
ELANE P08246 2/20 0.50
F7 P08709 1/20 0.50
F3 P13726 1/20 0.50
NOTUM Q6P988 1/20 0.49
KMT2A Q03164 4/20 0.48
ALDH1A1 P00352 3/20 0.48
HPGD P15428 2/20 0.48
F2 P00734 1/20 0.48
PGR P06401 1/20 0.48
MAPT P10636 2/20 0.47
HSD17B10 Q99714 1/20 0.47
MEN1 O00255 3/20 0.47
TP53 P04637 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPC1 O15118 4/20 0.45
KDM4E B2RXH2 1/20 0.45
C1R P00736 1/20 0.45
MGLL Q99685 1/20 0.45
RAB9A P51151 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10344443 0.88 ELANE (0.66) ELANEF7F3NOTUMKMT2A
SCHEMBL10741223 0.88 HPN (0.61) HPNELANEF7F3NOTUM
SCHEMBL5385483 0.86 F7 (0.49) HPNELANEF7F3NOTUM
SCHEMBL3452610 0.85 ELANE (0.60) HPNELANEF7F3KMT2A
SCHEMBL5371857 0.83 MAPT (0.64) HPNF7F3KMT2AALDH1A1
SCHEMBL14507130 0.80 RAB9A (0.58) ELANEF7F3KMT2AALDH1A1
SCHEMBL14273715 0.79 KDM4E (0.58) ELANEF7F3NOTUMKMT2A
SCHEMBL5380224 0.78 NPC1 (0.49) HPNELANEF7F3KMT2A
SCHEMBL14462682 0.77 F7 (0.45) HPNELANEF7F3KMT2A
SCHEMBL26818750 0.76 PTPN2 (0.63) KMT2AALDH1A1HPGDPGRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244776-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-07-17 US disclosed
US-20070100031-A1 Ultraviolet light absorbers RAVICHANDRAN RAMANATHAN 2007-05-03 US disclosed
US-7173128-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-02-06 US disclosed
US-20040192684-A1 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-30 US disclosed
EP-1430038-A1 ULTRAVIOLET LIGHT ABSORBERS Ciba SC Holding AG (CH) 2004-06-23 EP disclosed
WO-2003016292-A1 ULTRAVIOLET LIGHT ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192684-A1 Ultraviolet light absorbers UNG, MSH6, MAL2 HPN 1301/4885ELANE 1702/4885F7 1356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.