SCHEMBL10344906

SCHEMBL10344906

Cc1c(O)cc(F)c(C)c1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
MAPT P10636 2/20 0.42
GAA P10253 1/20 0.42
ACHE P22303 1/20 0.40
SELL P14151 1/20 0.35
SELP P16109 1/20 0.35
SELE P16581 1/20 0.35
CYP3A4 P08684 2/20 0.34
HSD17B10 Q99714 2/20 0.33
ADRB2 P07550 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
ADRA1A P35348 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
CASP1 P29466 1/20 0.33
PDE10A Q9Y233 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27120578 0.82 ALDH1A1 (0.36) ALDH1A1MAPTGAACYP3A4HDAC1
SCHEMBL21811691 0.81 ACHE (0.40) ALDH1A1MAPTGAAACHESELL
SCHEMBL21908936 0.81 ACHE (0.40) ALDH1A1MAPTGAAACHESELL
Hydrochloric Acid SCHEMBL25243100 0.79 ALDH1A1 (0.38) ALDH1A1MAPTGAACYP3A4HDAC1
Hydrochloric Acid SCHEMBL21811688 0.79 MAPT (0.41) ALDH1A1MAPTGAAACHESELL
SCHEMBL18745019 0.79 ALDH1A1 (0.41) ALDH1A1MAPTGAAACHESELL
SCHEMBL6833196 0.76 TSHR (0.43) ALDH1A1MAPTGAAACHESELL
SCHEMBL8079519 0.75 ALDH1A1 (0.50) ALDH1A1MAPTGAAACHECYP3A4
SCHEMBL24717973 0.75 ACHE (0.43) MAPTACHESELLSELPSELE
SCHEMBL14783927 0.74 ALDH1A1 (0.45) ALDH1A1MAPTGAAACHECYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0144195-B1 SQUARAINE COMPOSITIONS XEROX CORPORATION (US) 1990-04-11 EP disclosed