SCHEMBL1034491

SCHEMBL1034491

Cc1cc(C)c(C(=O)P(=O)(CCCCl)C(=O)c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.36
LMNA P02545 2/20 0.36
MEN1 O00255 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 2/20 0.36
TAS1R3 Q7RTX0 4/20 0.34
TAS1R1 Q7RTX1 4/20 0.34
TAS1R2 Q8TE23 4/20 0.34
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ITGB1 P05556 1/20 0.33
ITGA4 P13612 1/20 0.33
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
POLB P06746 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1035616 0.93 KMT2A (0.40) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL5160037 0.88 KMT2A (0.39) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL2497195 0.85 HPGD (0.41) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL691974 0.83 KMT2A (0.36) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL691870 0.83 GABBR2 (0.37) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL2064034 0.83 ITGB1 (0.41) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL6470163 0.82 LPAR3 (0.40) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL6467886 0.82 LPAR3 (0.40) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL6469685 0.82 LPAR3 (0.40) KMT2ALMNAMEN1SMN1; SMN2HPGD
SCHEMBL28251245 0.82 LPAR3 (0.40) KMT2ALMNAMEN1SMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2451847-B1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES IGM GROUP B V (NL) 2021-11-24 EP disclosed
US-9120900-B2 Polymer-bound bisacylphosphine oxides BASF SE (DE) 2015-09-01 US disclosed
US-20150025169-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2015-01-22 US disclosed
US-8883872-B2 Polymer-bound bisacylphosphine oxides BASF SE (DE) 2014-11-11 US disclosed
US-20120142805-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2012-06-07 US disclosed
EP-2451847-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2012-05-16 EP disclosed
WO-2011003772-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2011-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142805-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES PHOSPHO1, PARG, PEBP1 KMT2A 2704/4885LMNA 2500/4885MEN1 1570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.