Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901160 | 0.84 | ALDH1A1 (0.37) | KDM4ECACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL10345388 | 0.83 | SQOR (0.37) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL10345348 | 0.82 | NR4A2 (0.42) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL8953266 | 0.81 | — | — | |
| SCHEMBL8953273 | 0.81 | — | — | |
| SCHEMBL10345393 | 0.76 | — | — | |
| SCHEMBL8901153 | 0.75 | KDM4E (0.38) | KDM4ECACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL10345400 | 0.74 | CTSA (0.34) | HMGCR | |
| SCHEMBL10442264 | 0.73 | HMGCR (0.51) | HMGCRALDH1A1 | |
| SCHEMBL8877867 | 0.72 | KDM4E (0.39) | KDM4ECACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | claimed |
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |