SCHEMBL1034531

SCHEMBL1034531

C#CCP(C(=O)c1c(C)cc(C)cc1C)C(=O)c1c(C)cc(C)cc1C

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
LMNA P02545 3/20 0.35
HPGD P15428 2/20 0.35
KDM4E B2RXH2 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MCOLN3 Q8TDD5 1/20 0.35
ALDH1A1 P00352 4/20 0.33
MAPT P10636 2/20 0.33
MAPK1 P28482 1/20 0.33
TAS1R3 Q7RTX0 2/20 0.33
TAS1R1 Q7RTX1 2/20 0.33
TAS1R2 Q8TE23 2/20 0.33
GAA P10253 2/20 0.32
POLB P06746 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1037184 0.76 LMNA (0.38) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL1034997 0.74 KDM4E (0.40) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL5566593 0.73 HPGD (0.39) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL21111136 0.73 KMT2A (0.39) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL15637944 0.73 SMN1; SMN2 (0.39) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL12956434 0.73 LMNA (0.40) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL1034981 0.72 THRB (0.35) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL20636994 0.71 NPSR1 (0.40) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL1035817 0.70 KDM4E (0.37) MEN1KMT2ALMNAHPGDKDM4E
SCHEMBL691938 0.70 HPGD (0.34) MEN1KMT2ALMNAHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2451847-B1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES IGM GROUP B V (NL) 2021-11-24 EP disclosed
US-9120900-B2 Polymer-bound bisacylphosphine oxides BASF SE (DE) 2015-09-01 US disclosed
US-20150025169-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2015-01-22 US disclosed
US-8883872-B2 Polymer-bound bisacylphosphine oxides BASF SE (DE) 2014-11-11 US disclosed
US-20120142805-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2012-06-07 US disclosed
EP-2451847-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2012-05-16 EP disclosed
WO-2011003772-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2011-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142805-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES PHOSPHO1, PARG, PEBP1 MEN1 1570/4885KMT2A 2704/4885LMNA 2500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.