Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 3/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11036272 | 0.92 | CA2 (0.84) | CA2CA12CA1CA9CNR1 | |
| SCHEMBL10345582 | 0.87 | CA2 (1.00) | CA2CA12CA1CA9CNR1 | |
| SCHEMBL7245923 | 0.79 | CA2 (0.65) | CA2CA12CA1CA9CNR1 | |
| SCHEMBL10573193 | 0.77 | CA2 (0.62) | CA2CA12CA1CA9KDM4E | |
| SCHEMBL31060504 | 0.75 | CNR1 (1.00) | CA2CNR1 | |
| SCHEMBL10345596 | 0.75 | CA2 (1.00) | CA2PDGFRBPDGFRAFLT3 | |
| SCHEMBL13264145 | 0.74 | AXL (0.65) | CA2CA12CA1CA9AXL | |
| SCHEMBL4630184 | 0.74 | CA2 (0.58) | CA2CA12CA1CA9CNR1 | |
| SCHEMBL10573349 | 0.73 | CA2 (0.57) | CA2CA12CA1CA9CNR1 | |
| SCHEMBL10573298 | 0.73 | CA2 (0.57) | CA2CA12CA1CA9CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155214-B1 | 2-SULFAMOYL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4840963-A | FOR GLAUCOMA | MERCK & CO., INC. (US) | 1989-06-20 | — | — | US | disclosed |
| EP-0155214-A2 | 2-sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-09-18 | — | — | EP | disclosed |