Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 1.00 |
| ▸ | FLT3 | P36888 | 7/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11036272 | 0.87 | CA2 (0.84) | CA2FLT3PDGFRBPDGFRA | |
| SCHEMBL10345382 | 0.86 | CA2 (1.00) | CA2 | |
| SCHEMBL10573479 | 0.79 | CA2 (0.66) | CA2 | |
| SCHEMBL32681985 | 0.76 | CA2 (1.00) | CA2FLT3 | |
| SCHEMBL32895 | 0.76 | CA2 (1.00) | CA2FLT3 | |
| SCHEMBL10345372 | 0.75 | CA2 (1.00) | CA2FLT3PDGFRBPDGFRA | |
| SCHEMBL529968 | 0.71 | FLT3 (0.55) | CA2FLT3PDGFRBABL1KIT | |
| SCHEMBL830973 | 0.70 | CA2 (0.54) | CA2FLT3PDGFRBABL1KIT | |
| SCHEMBL2454392 | 0.70 | FLT3 (0.59) | CA2FLT3PDGFRBABL1KIT | |
| SCHEMBL32666155 | 0.70 | FLT3 (0.59) | CA2FLT3PDGFRBABL1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155214-B1 | 2-SULFAMOYL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4840963-A | FOR GLAUCOMA | MERCK & CO., INC. (US) | 1989-06-20 | — | — | US | disclosed |
| EP-0155214-A2 | 2-sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-09-18 | — | — | EP | disclosed |