Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HCN1 | O60741 | 3/20 | 0.44 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345569 | 0.82 | CHRM2 (0.58) | ALDH1A1L3MBTL1HSD17B10AVPR1AAVPR1B | |
| SCHEMBL10345634 | 0.80 | SIGMAR1 (0.45) | ALDH1A1L3MBTL1HCN1HCN4OPRM1 | |
| Hydrochloric Acid SCHEMBL10345568 | 0.79 | SIGMAR1 (0.44) | ALDH1A1L3MBTL1HCN1HCN4OPRM1 | |
| SCHEMBL10345149 | 0.77 | CHRM2 (0.53) | ALDH1A1AVPR1AAVPR1BKMT2ASSTR5 | |
| SCHEMBL10345233 | 0.75 | SLC6A2 (0.41) | ALDH1A1L3MBTL1HCN1HCN4HPGD | |
| Acetic Acid SCHEMBL10974566 | 0.73 | CHRM2 (0.54) | ALDH1A1AVPR1AAVPR1BSSTR5 | |
| SCHEMBL10345603 | 0.73 | HSP90AA1 (0.42) | SSTR4OPRM1ADRA1AOPRD1KMT2A | |
| SCHEMBL10345611 | 0.72 | ACHE (0.44) | ALDH1A1L3MBTL1ADRA1AAVPR1AAVPR1B | |
| Iodide SCHEMBL10345164 | 0.72 | ACHE (0.43) | ALDH1A1L3MBTL1ADRA1AAVPR1AAVPR1B | |
| SCHEMBL29346751 | 0.71 | OPRM1 (0.35) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152236-B1 | ARYLOXYMETHYLPYRROLIDINOLS AND PIPERIDINOLS HAVING ANTIDEPRESSANT, ANTIARHYTHMIC OR HYPOTENSIVE ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-04-18 | — | — | EP | claimed |
| EP-0152236-A2 | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarhythmic or hypotensive activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-08-21 | — | — | EP | claimed |
| US-4508724-A | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity | A. H. ROBINS COMPANY, INC. (US) | 1985-04-02 | — | — | US | claimed |
| EP-0152236-A2 | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarhythmic or hypotensive activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4508724-A | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity | A. H. ROBINS COMPANY, INC. (US) | 1985-04-02 | — | — | US | disclosed |