Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 13/20 | 0.57 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.54 |
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.53 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.53 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.46 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.53 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.53 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.53 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.53 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.53 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.53 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10345846 | 1.00 | DRD1 (0.57) | DRD1DRD5HTR2CDRD2KDM4E | |
| Maleic Acid SCHEMBL8147693 | 0.82 | TAAR1 (0.76) | DRD1DRD5HTR2CDRD2KDM4E | |
| Fumaric Acid SCHEMBL8147697 | 0.82 | TAAR1 (0.76) | DRD1DRD5HTR2CDRD2KDM4E | |
| SCHEMBL7629630 | 0.81 | HTR2C (0.66) | DRD1DRD5HTR2CDRD2KDM4E | |
| Hydrochloric Acid SCHEMBL10345386 | 0.80 | DRD1 (0.66) | DRD1DRD5HTR2CDRD2KDM4E | |
| SCHEMBL29356733 | 0.78 | MEN1 (0.60) | DRD1DRD5HTR2CDRD2CYP3A4 | |
| SCHEMBL11639387 | 0.78 | MEN1 (0.60) | DRD1DRD5HTR2CDRD2CYP3A4 | |
| Fumaric Acid SCHEMBL11160727 | 0.75 | DRD1 (0.58) | DRD1DRD5DRD2KDM4EHPGD | |
| Fumaric Acid SCHEMBL11160742 | 0.75 | DRD1 (0.58) | DRD1DRD5DRD2KDM4EHPGD | |
| SCHEMBL11710309 | 0.75 | DRD1 (0.73) | DRD1DRD5DRD2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230755-B1 | 1-PHENYL-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0244088-A2 | 1-Phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0230755-A1 | 1-Phenyl-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-05 | — | — | EP | disclosed |