Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 14/20 | 0.59 |
| ▸ | DRD2 known ✓ | P14416 | 9/20 | 0.59 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.57 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.55 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | DRD5 | P21918 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.57 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.57 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.57 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.57 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.57 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8147693 | 1.00 | TAAR1 (0.76) | TAAR1DRD1DRD2KDM4EHPGD | |
| SCHEMBL2566292 | 0.88 | TAAR1 (0.97) | TAAR1DRD1DRD2KDM4EHPGD | |
| Fumaric Acid SCHEMBL10345846 | 0.82 | DRD1 (0.57) | TAAR1DRD1DRD2KDM4EHPGD | |
| Maleic Acid SCHEMBL10345844 | 0.82 | DRD1 (0.57) | TAAR1DRD1DRD2KDM4EHPGD | |
| Fumaric Acid SCHEMBL175130 | 0.82 | HTR2C (0.74) | TAAR1ADRA2CBLMHTR2AHTR2C | |
| Maleic Acid SCHEMBL174415 | 0.82 | HTR2C (0.74) | TAAR1ADRA2CBLMHTR2AHTR2C | |
| Fumaric Acid SCHEMBL174417 | 0.82 | HTR2C (0.74) | TAAR1ADRA2CBLMHTR2AHTR2C | |
| Maleic Acid SCHEMBL161822 | 0.78 | TAAR1 (0.46) | TAAR1DRD1DRD2MAPTCYP2C9 | |
| Fumaric Acid SCHEMBL159722 | 0.78 | TAAR1 (0.46) | TAAR1DRD1DRD2MAPTCYP2C9 | |
| Fumaric Acid SCHEMBL12504899 | 0.77 | HTR2C (0.64) | TAAR1DRD1DRD2KDM4EDRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043980-A2 | METHOD OF REDUCING CRAVING IN MAMMALS | SCHERING CORPORATION (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999021540-A2 | METHOD OF REDUCING CRAVING IN MAMMALS | SCHERING CORPORATION (US) | 1999-05-06 | — | — | WO | disclosed |