Sugi Predict

Sugi Predict / Compounds / SCHEMBL1034658

SCHEMBL1034658

SCHEMBL1034658

O=C(Nc1cccc(F)c1)OCc1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 4/20 0.74
▸ ENPP2 Q13822 3/20 0.64
▸ POLB P06746 1/20 0.58
▸ NPC1 O15118 2/20 0.56
▸ RAB9A P51151 2/20 0.56
▸ ALDH1A1 P00352 1/20 0.56
▸ TP53 P04637 1/20 0.56
▸ MAPT P10636 1/20 0.56
▸ TSHR P16473 1/20 0.56
▸ ATM Q13315 1/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ MEN1 O00255 1/20 0.55
▸ KMT2A Q03164 1/20 0.55
▸ HPGD P15428 1/20 0.55
▸ LRRK2 Q5S007 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4577453 0.92 MGLL (0.65) MGLLENPP2POLBNPC1RAB9A
SCHEMBL7122137 0.88 MGLL (0.65) MGLLENPP2POLBNPC1RAB9A
SCHEMBL38652348 0.87 MGLL (0.57) MGLLENPP2POLBNPC1RAB9A
SCHEMBL8984657 0.85 MGLL (0.76) MGLLENPP2POLBNPC1RAB9A
Benzyl Phenylcarbamate SCHEMBL1222943 0.84 POLB (0.78) MGLLENPP2POLBNPC1RAB9A
SCHEMBL27498433 0.84 MGLL (0.74) MGLLENPP2POLBNPC1RAB9A
SCHEMBL27815058 0.83 MGLL (0.71) MGLLPOLBNPC1RAB9AALDH1A1
SCHEMBL4678478 0.83 MGLL (0.71) MGLLENPP2POLBNPC1RAB9A
SCHEMBL3780832 0.83 MGLL (0.68) MGLLENPP2POLBNPC1RAB9A
SCHEMBL4156354 0.83 HDAC8 (0.60) MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3442526-B1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA SUBSIDIARY CORP (US) 2023-01-04 — — EP disclosed
CN-110078764-B Preparation method of oxazolidinone compound 博瑞生物医药（苏州）股份有限公司 2021-10-26 — — CN disclosed
US-20210121449-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2021-04-29 — — US disclosed
US-20200078345-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2020-03-12 — — US disclosed
US-10471046-B2 Method for treating, preventing, or reducing the risk of skin infection MELINTA SUBSIDARY CORP. (US) 2019-11-12 — — US disclosed
CN-106146559-B Preparation method of oxazolidinone compound 博瑞生物医药（苏州）股份有限公司 2019-08-09 — — CN disclosed
CN-110078764-A A kind of preparation method of Oxazolidinone derivative 博瑞生物医药（苏州）股份有限公司 2019-08-02 — — CN disclosed
EP-3442526-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF Melinta Subsidiary Corp. (US) 2019-02-20 — — EP disclosed
US-20180344716-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2018-12-06 — — US disclosed
US-20170333400-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA SUBSIDIARY CORP. 2017-11-23 — — US disclosed
EP-0673370-B1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS UPJOHN CO (US) 1998-01-07 — — EP disclosed
US-5654435-A BACTERICIDES PHARMACIA & UPJOHN COMPANY (US) 1997-08-05 — — US disclosed
US-5654428-A BACTERICIDES PHARMACIA & UPJOHN COMPANY (US) 1997-08-05 — — US disclosed
EP-0610265-B1 SUBSTITUTED ARYL- AND HETEROARYLPHENYLOXAZOLIDINONES USEFUL AS ANTIBACTERIAL AGENTS UPJOHN CO (US) 1996-12-27 — — EP disclosed
US-5565571-A BACTERICIDES THE UPJOHN COMPANY (US) 1996-10-15 — — US disclosed
US-5523403-A Tropone-substituted phenyloxazolidinone antibacterial agents THE UPJOHN COMPANY (US) 1996-06-04 — — US disclosed
EP-0673370-A1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1995-09-27 — — EP disclosed
EP-0610265-A1 SUBSTITUTED ARYL- AND HETEROARYLPHENYLOXAZOLIDINONES USEFUL AS ANTIBACTERIAL AGENTS. UPJOHN CO (US) 1994-08-17 — — EP disclosed
WO-1994013649-A1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS THE UPJOHN COMPANY (US) 1994-06-23 — — WO disclosed
WO-1993009103-A1 SUBSTITUTED ARYL- AND HETEROARYLPHENYLOXAZOLIDINONES USEFUL AS ANTIBACTERIAL AGENTS THE UPJOHN COMPANY (US) 1993-05-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121449-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI MGLL 2878/4885ENPP2 4083/4885POLB 158/4885
US-20170333400-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF CUTA, CYP19A1, KAT2A MGLL 667/4885ENPP2 1148/4885POLB 1387/4885
US-20200078345-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI MGLL 2878/4885ENPP2 4083/4885POLB 158/4885
US-10471046-B2 Method for treating, preventing, or reducing the risk of skin infection CUTA, CYP17A1, HSD17B11 MGLL 715/4885ENPP2 3221/4885POLB 284/4885
US-20180344716-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI MGLL 2878/4885ENPP2 4083/4885POLB 158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.