Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.55 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346307 | 0.90 | LMNA (0.61) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL16120975 | 0.87 | ADORA2B (0.88) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL10346583 | 0.87 | PDE4A (0.64) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL16120989 | 0.86 | ADORA2B (0.85) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL16121000 | 0.86 | ADORA2B (0.85) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL16120983 | 0.86 | ADORA2B (0.85) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL16120982 | 0.86 | ADORA2B (0.85) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL16120999 | 0.86 | ADORA2B (0.85) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL19969384 | 0.86 | ADORA2B (0.85) | ADORA2BMAPK1RXFP1LMNAMAPT | |
| SCHEMBL7030926 | 0.86 | PDE4A (0.62) | ADORA2BMAPK1RXFP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268585-B1 | TERTIARY HYDROXYALKYLXANTHINES, THEIR MANUFACTURING PROCESS, MEDICINES CONTAINING THEM AND USE THEREOF | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| US-4833146-A | BRAINS, BLOOD DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-23 | — | — | US | disclosed |