Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3110029 | 0.94 | KDM4E (0.37) | ALDH1A1KDM4EHSD17B10TP53LMNA | |
| SCHEMBL3108617 | 0.91 | MEN1 (0.36) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL871002 | 0.91 | KMT2A (0.36) | ALDH1A1KDM4EMAPTALPGALPL | |
| SCHEMBL1036065 | 0.90 | PDK2 (0.36) | TP53LMNAMAPTHPGDCNR1 | |
| SCHEMBL3109810 | 0.89 | LMNA (0.33) | KDM4ETP53LMNAMAPK1NPC1 | |
| SCHEMBL3123578 | 0.89 | ACACB (0.38) | — | |
| SCHEMBL3115589 | 0.88 | POLR1A (0.34) | KDM4ETP53LMNA | |
| SCHEMBL16687347 | 0.88 | ORAI1 (0.34) | — | |
| SCHEMBL1034275 | 0.88 | PTGES (0.35) | KDM4ETP53LMNAMAPTALPG | |
| SCHEMBL3110825 | 0.88 | TDP1 (0.34) | ALDH1A1KDM4ETP53LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-02-06 | — | — | US | claimed |
| US-20130029845-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-01-31 | — | — | US | claimed |
| US-7964204-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-21 | — | — | US | claimed |
| EP-1973888-B1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2011-01-26 | — | — | EP | claimed |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | CORTEVA AGRISCIENCE LLC | 2010-09-16 | — | — | US | claimed |
| EP-3222618-A1 | NAPTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. du Pont de Nemours and Company (US) | 2017-09-27 | — | — | EP | disclosed |
| US-8871941-B2 | 8-bromo-5-quinolinecarboxaldehyde oxime | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-10-28 | — | — | US | disclosed |
| US-20140249314-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140113943-A9 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | E.I. DU PONT DE NEMOURS AND COMPANY | 2014-04-24 | — | — | US | disclosed |
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-02-06 | — | — | US | disclosed |
| US-8552218-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20130217736-A1 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | DU PONT (US) | 2013-08-22 | — | — | US | disclosed |
| US-8231888-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110263641-A1 | Isoxazolines For Controlling Invertebrate Pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-7964204-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1973888-B1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100254959-A1 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | CORTEVA AGRISCIENCE LLC | 2010-09-16 | — | — | US | disclosed |
| EP-2158188-A2 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. Du Pont de Nemours and Company (US) | 2010-03-03 | — | — | EP | disclosed |
| WO-2009002809-A2 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100254959-A1 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | C1S, C1R, C9 | ALDH1A1 1910/4885KDM4E 3583/4885HSD17B10 970/4885 |
| US-20130217736-A1 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | C1S, C1R, C9 | ALDH1A1 1910/4885KDM4E 3583/4885HSD17B10 970/4885 |
| US-20140249314-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | ALDH1A1 1132/4885KDM4E 4196/4885HSD17B10 2569/4885 |
| US-20140113943-A9 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | C1S, C1R, C9 | ALDH1A1 1910/4885KDM4E 3583/4885HSD17B10 970/4885 |
| US-20130029845-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | ALDH1A1 1132/4885KDM4E 4196/4885HSD17B10 2569/4885 |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | C1S, C3AR1, CBR3 | ALDH1A1 904/4885KDM4E 4124/4885HSD17B10 2604/4885 |
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | ALDH1A1 1132/4885KDM4E 4196/4885HSD17B10 2569/4885 |
| US-20110263641-A1 | Isoxazolines For Controlling Invertebrate Pests | C1S, C3AR1, CBR3 | ALDH1A1 1263/4885KDM4E 4249/4885HSD17B10 2670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.