Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | PGR | P06401 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | IL5 | P05113 | 1/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.65 |
| ▸ | AR | P10275 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.65 |
| ▸ | THPO | P40225 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10799262 | 1.00 | CYP3A4 (0.65) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| SCHEMBL10337827 | 0.89 | CYP3A4 (0.73) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| SCHEMBL7134775 | 0.89 | CYP3A4 (0.73) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| SCHEMBL7741442 | 0.89 | CYP3A4 (0.73) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| Dexbudesonide SCHEMBL1302753 | 0.86 | NR3C1 (0.73) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| SCHEMBL26228053 | 0.83 | LMNA (0.65) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| SCHEMBL13985476 | 0.83 | NR3C1 (0.75) | CYP3A4HIF1ALMNANR3C1NFKB1 | |
| SCHEMBL20149515 | 0.82 | NR3C1 (0.63) | CYP3A4HIF1ALMNANR3C1ABCB11 | |
| SCHEMBL7741861 | 0.82 | LMNA (0.64) | CYP3A4HIF1ALMNANR3C1NFKB1 | |
| SCHEMBL20226715 | 0.81 | CYP3A4 (0.55) | CYP3A4HIF1ALMNANR3C1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164636-B1 | A PROCESS FOR THE PREPARATION OF 16,17 ACETALS OF PREGNANE DERIVATIVES AND COMPOUNDS OBTAINED THEREFROM | SICOR Società Italiana Corticosteroidi S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |