Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.75 |
| ▸ | PGR | P06401 | 8/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.65 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | AR | P10275 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741442 | 0.94 | CYP3A4 (0.73) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL7134775 | 0.94 | CYP3A4 (0.73) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL10337827 | 0.94 | CYP3A4 (0.73) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL1638192 | 0.90 | NR3C1 (0.78) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL12140907 | 0.90 | NR3C1 (0.78) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL22601611 | 0.90 | NR3C1 (0.78) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL13214375 | 0.89 | NR3C1 (0.68) | NR3C1PGRHIF1ACYP3A4LMNA | |
| Acrocinonide SCHEMBL11880454 | 0.88 | NR3C1 (0.74) | NR3C1PGRHIF1ACYP3A4LMNA | |
| Acrocinonide SCHEMBL1813445 | 0.88 | NR3C1 (0.74) | NR3C1PGRHIF1ACYP3A4LMNA | |
| SCHEMBL26228053 | 0.88 | LMNA (0.65) | NR3C1PGRHIF1ACYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470724-B2 | Phosphonate compounds having immuno-modulatory activity | GILEAD SCIENCES, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |