Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299753 | 0.85 | TDP1 (0.68) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL9867402 | 0.84 | KDR (0.70) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL11264182 | 0.82 | SMN1; SMN2 (0.60) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL5503426 | 0.81 | NPC1 (0.58) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL9868437 | 0.81 | KDM4E (0.59) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL10520574 | 0.80 | CYP1A2 (0.72) | METAP2NPC1RAB9APOLBGAA | |
| SCHEMBL8341671 | 0.79 | POLB (0.63) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL12949077 | 0.79 | NPC1 (0.56) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL971803 | 0.78 | TDP1 (0.64) | NPC1RAB9ATDP1SMN1; SMN2HTT | |
| SCHEMBL3088776 | 0.78 | NPC1 (0.55) | NPC1RAB9ATDP1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257306-B1 | DISELENOBIS BENZOIC ACID AMIDES OF PRIMARY HETEROCYCLIC AMINES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOUNDS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0257306-A1 | Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and pharmaceutical compounds comprising the same | A. Nattermann & Cie. GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |