Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Aminomethylenebisphosphonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 6/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | LAP3 | P28838 | 4/20 | 0.39 |
| ▸ | GLUL | P15104 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminomethylenebisphosphonic Acid SCHEMBL7769358 | 0.92 | KDM4E (0.62) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL78977 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL19350137 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1485658 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL7743864 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL9550946 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL12492957 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2823010 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1707898 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2353950 | 0.86 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103416-B2 | Peroxyacid bleach compositions | THE PROCTER & GAMBLE COMPANY (US) | 1990-08-16 | — | — | EP | disclosed |
| EP-0103416-B1 | Peroxyacid bleach compositions | THE PROCTER & GAMBLE COMPANY (US) | 1986-11-05 | — | — | EP | disclosed |