Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2466923 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL4631149 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL7893413 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL11529637 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL9344673 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL11587440 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL786724 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL8663181 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL786259 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 | |
| Bicarbonate SCHEMBL14152424 | 1.00 | NAAA (0.52) | NAAACES2HCAR2EPHX1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010986-B2 | PROCESS FOR THE PREPARATION OF POLYMER LATEX | SINTEF (NO) | 1990-08-29 | — | — | EP | disclosed |
| EP-0010986-B1 | PROCESS FOR THE PREPARATION OF POLYMER LATEX | SINTEF (NO) | 1983-11-02 | — | — | EP | disclosed |