Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10799696 | 0.84 | ACP3 (0.48) | ESR1ACHEACP3GAALMNA | |
| SCHEMBL10596765 | 0.80 | IDO1 (0.39) | ALDH1A1GAALMNATSHRPOLB | |
| SCHEMBL11615386 | 0.79 | ESR1 (0.54) | ESR1ACHEACP3ALDH1A1GAA | |
| SCHEMBL17055437 | 0.77 | GAA (0.53) | ESR1SLC6A9ACHEACP3ALDH1A1 | |
| SCHEMBL1585335 | 0.77 | GAA (0.53) | ESR1SLC6A9ACHEACP3ALDH1A1 | |
| SCHEMBL6485306 | 0.74 | TSHR (0.48) | ALDH1A1LMNATSHRCNR2IDO1 | |
| SCHEMBL29083677 | 0.74 | CYP2D6 (0.52) | ESR1TSHR | |
| SCHEMBL30575789 | 0.74 | ALDH1A1 (0.46) | ALDH1A1TSHR | |
| SCHEMBL424538 | 0.73 | IDO1 (0.46) | ACHEALDH1A1LMNAIDO1TDO2 | |
| SCHEMBL22731532 | 0.73 | SLC6A9 (0.39) | ESR1SLC6A9ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243904-B1 | Optionally substituted 1-(2'-[bis-(phenyl)-methoxy]-ethyl)-4-(3'[bis-(phenyl)-methoxy]propyl)piperazines, process for their preparation and medicines containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1990-10-31 | — | — | EP | disclosed |
| US-4866062-A | TREATMENT OF DISEASES ARISING FROM A HYPOFUNCTION OF THE DOPAMINERGIC SYSTEM | RICHTER GEDEON VEGYESZETI GYAR (HU) | 1989-09-12 | — | — | US | disclosed |
| EP-0243904-A1 | Optionally substituted 1-(2'-[bis-(phenyl)-methoxy]-ethyl)-4-(3'[bis-(phenyl)-methoxy]propyl)piperazines, process for their preparation and medicines containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1987-11-04 | — | — | EP | disclosed |