Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | VRK2 | Q86Y07 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 7/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TPO | P07202 | 1/20 | 0.33 |
| ▸ | EPX | P11678 | 1/20 | 0.33 |
| ▸ | LPO | P22079 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646277 | 0.85 | MAPK14 (0.37) | GPR119PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL1677224 | 0.80 | GPR119 (0.33) | GPR119PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL2645388 | 0.76 | MAPT (0.40) | GCK | |
| SCHEMBL2361400 | 0.75 | L3MBTL1 (0.43) | GPR119PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL564713 | 0.75 | ALDH1A1 (0.47) | GPR119PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL2644241 | 0.75 | BACE1 (0.36) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL2646749 | 0.74 | GCK (0.36) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL1677227 | 0.74 | MMP2 (0.43) | GPR119PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL2646047 | 0.73 | MAPT (0.39) | — | |
| SCHEMBL2646549 | 0.72 | GCK (0.36) | PIK3CDSCN9AGCKMPOTPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276760-A1 | FUSED RING COMPOUNDS AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009125873-A1 | FUSED RING COMPOUNDS AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-15 | — | — | WO | disclosed |