Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | GFER | P55789 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725629 | 0.92 | HTR1A (0.78) | HTR1ADRD2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10359740 | 0.84 | MAPT (0.60) | HTR1ADRD2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11794673 | 0.83 | SIGMAR1 (0.74) | HTR1ADRD2MAPTSIGMAR1KDM4E | |
| SCHEMBL11563433 | 0.82 | SIGMAR1 (0.79) | HTR1ADRD2CYP2D6SIGMAR1 | |
| SCHEMBL1509554 | 0.81 | LMNA (0.70) | MAPTALDH1A1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL15651612 | 0.81 | MAPT (0.65) | HTR1ADRD2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6152128 | 0.81 | MAPT (0.65) | HTR1ADRD2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3440162 | 0.81 | MAPT (0.65) | DRD2MAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1877934 | 0.81 | HRH3 (0.68) | ALDH1A1TDP1CYP1A2CYP3A4SIGMAR1 | |
| SCHEMBL5651768 | 0.81 | SIGMAR1 (0.64) | MAPTALDH1A1SMN1; SMN2MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257864-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-12-05 | — | — | EP | claimed |
| EP-0257864-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-03-02 | — | — | EP | claimed |
| EP-0257864-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4797401-A | 4-Substituted-1-(4-alkylsulphonamidophenyl)piperazines as antiarrhythmic agents | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0257864-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-03-02 | — | — | EP | disclosed |