Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.66 |
| ▸ | HTR2C | P28335 | 9/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | MLNR | O43193 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 7/20 | 0.54 |
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7014506 | 0.98 | HTR6 (0.64) | HTR6HTR2CHTR2ADRD2DRD3 | |
| SCHEMBL8115507 | 0.90 | HTR6 (0.55) | HTR6HTR2CHTR2ADRD2DRD3 | |
| SCHEMBL3249580 | 0.90 | PNMT (0.62) | HTR6HTR2CHTR2ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL4789165 | 0.89 | HTR6 (0.54) | HTR6HTR2CHTR2ADRD2DRD3 | |
| SCHEMBL30023674 | 0.84 | LMNA (0.64) | LMNAALDH1A1THRBSMN1; SMN2L3MBTL1 | |
| SCHEMBL18422825 | 0.84 | LMNA (0.64) | LMNAALDH1A1THRBSMN1; SMN2L3MBTL1 | |
| SCHEMBL15220226 | 0.84 | LMNA (0.59) | HTR6LMNAALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL1946627 | 0.81 | LMNA (0.77) | HTR6HTR2CHTR2ADRD2DRD3 | |
| SCHEMBL2768256 | 0.80 | HDAC3 (0.46) | HTR6HTR2CHTR2ADRD2DRD3 | |
| SCHEMBL5781306 | 0.80 | HTR6 (1.00) | HTR6HTR2CHTR2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284384-B1 | ANTI-ARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4891372-A | Antiarrhythmic agents, compositions and method of use thereas | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0284384-A1 | Anti-arrhythmic agents | Pfizer Limited (GB) | 1988-09-28 | — | — | EP | disclosed |