Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.62 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.54 |
| ▸ | MELK | Q14680 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115507 | 0.94 | HTR6 (0.55) | PNMTHTR6DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL4789165 | 0.92 | HTR6 (0.54) | PNMTHTR6DRD2HTR2AHTR2C | |
| SCHEMBL10360424 | 0.90 | HTR6 (0.66) | PNMTHTR6DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7014506 | 0.89 | HTR6 (0.64) | PNMTHTR6DRD2HTR2AHTR2C | |
| SCHEMBL14067448 | 0.86 | HTR6 (0.55) | PNMTHTR6DRD2HTR2AHTR2C | |
| SCHEMBL6925873 | 0.86 | PNMT (0.56) | PNMTHTR6DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL28416949 | 0.85 | HTR6 (0.53) | PNMTHTR6DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL31084057 | 0.85 | HTR6 (0.53) | PNMTHTR6DRD2HTR2AHTR2C | |
| SCHEMBL13757776 | 0.81 | PNMT (0.76) | PNMTHTR6DRD2HTR2AHTR2C | |
| SCHEMBL7452220 | 0.81 | HTR6 (0.84) | PNMTHTR6DRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | disclosed |
| US-7393875-B2 | Reducing islet amyloid polypeptide (IAPP) associated deposit; type II diabetes | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2008-07-01 | — | — | US | disclosed |
| US-7268142-B2 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PFIZER INC. (US) | 2007-09-11 | — | — | US | disclosed |