Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10360780 | 0.88 | LTA4H (0.54) | LTA4HHRH3DRD2SLC6A4ADRA1D | |
| SCHEMBL7859721 | 0.82 | LTA4H (0.88) | LTA4HHRH3NPC1RAB9AKCNH2 | |
| SCHEMBL9124515 | 0.81 | LTA4H (0.73) | LTA4HHRH3NPC1RAB9AGRIN1 | |
| SCHEMBL10360469 | 0.81 | DRD2 (0.56) | DRD2ABCB1DRD3KCNH2 | |
| Water SCHEMBL9125025 | 0.80 | LTA4H (0.71) | LTA4HHRH3NPC1RAB9AGRIN1 | |
| SCHEMBL9807583 | 0.79 | LTA4H (0.56) | LTA4HHRH3NPC1RAB9AGRIN1 | |
| SCHEMBL9428861 | 0.78 | LTA4H (0.61) | LTA4HNPC1RAB9AGRIN1GRIN2B | |
| SCHEMBL9472050 | 0.78 | LTA4H (0.68) | LTA4HHRH3NPC1RAB9AGRIN1 | |
| Hydrochloric Acid SCHEMBL9428533 | 0.78 | LTA4H (0.60) | LTA4HNPC1RAB9AGRIN1GRIN2B | |
| SCHEMBL6397956 | 0.77 | LTA4H (0.59) | LTA4HHRH3NPC1RAB9AGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284384-B1 | ANTI-ARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-11-28 | — | — | EP | claimed |
| US-4891372-A | Antiarrhythmic agents, compositions and method of use thereas | PFIZER INC. (US) | 1990-01-02 | — | — | US | claimed |
| US-4891372-A | Antiarrhythmic agents, compositions and method of use thereas | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0284384-A1 | Anti-arrhythmic agents | Pfizer Limited (GB) | 1988-09-28 | — | — | EP | disclosed |