SCHEMBL10360740

SCHEMBL10360740

O=C(Oc1ccccc1)C1(C(=O)Oc2ccccc2)C=CC(C=Cc2ccccc2)=CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAD51 Q06609 1/20 0.40
KMT2A Q03164 3/20 0.37
POLB P06746 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PPARA Q07869 1/20 0.33
PTPN1 P18031 1/20 0.33
HNF4A P41235 1/20 0.33
HDAC1 Q13547 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
HDAC3 O15379 1/20 0.33
TNKS O95271 1/20 0.33
HDAC4 P56524 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
TNKS2 Q9H2K2 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9639696 0.85 ALDH1A1 (0.38) KMT2APOLBHDAC1SMN1; SMN2ALDH1A1
SCHEMBL809497 0.83 HDAC1 (0.38) KMT2APTPN1HNF4AHDAC1SMN1; SMN2
SCHEMBL5082374 0.83 HDAC1 (0.38) KMT2APTPN1HNF4AHDAC1SMN1; SMN2
SCHEMBL27447417 0.83 HDAC1 (0.38) KMT2APTPN1HNF4AHDAC1SMN1; SMN2
SCHEMBL3090330 0.81 LMNA (0.47) KMT2AL3MBTL1SMN1; SMN2HCAR2ALDH1A1
SCHEMBL3090328 0.81 LMNA (0.47) KMT2AL3MBTL1SMN1; SMN2HCAR2ALDH1A1
SCHEMBL9546943 0.81 HDAC1 (0.36) PTPN1HNF4AHDAC1SMN1; SMN2HDAC3
Alcohol SCHEMBL29274513 0.77 L3MBTL1 (0.36) KMT2AL3MBTL1PTPN1HNF4AHDAC1
SCHEMBL27570573 0.73 HDAC1 (0.37) KMT2APTPN1HNF4AHDAC1SMN1; SMN2
SCHEMBL2532692 0.72 TTR (0.37) KMT2APTPN1HNF4AHDAC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0396564-A1 PROCESS FOR THE PREPARATION OF STILBENEDICARBOXYLATE DERIVATIVES EASTMAN KODAK COMPANY (US) 1990-11-14 EP disclosed
WO-1989003380-A1 PROCESS FOR THE PREPARATION OF STILBENEDICARBOXYLATE DERIVATIVES EASTMAN KODAK COMPANY (US) 1989-04-20 WO disclosed