Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013274 | 0.85 | CASP1 (0.40) | ALOX5ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL4209917 | 0.82 | GRM1 (0.46) | POLBTDP1L3MBTL1GAA | |
| SCHEMBL6037567 | 0.72 | KDR (0.42) | ALOX5PARP1ALDH1A1HPGDPOLB | |
| SCHEMBL22336310 | 0.71 | ALDH1A1 (0.44) | ALOX5ALDH1A1HPGDTDP1GAA | |
| SCHEMBL29940563 | 0.70 | POLB (0.45) | POLBGAAHTT | |
| SCHEMBL20264395 | 0.70 | POLB (0.45) | POLBGAAHTT | |
| SCHEMBL30545003 | 0.68 | POLB (0.35) | ALDH1A1HPGDPOLBTDP1L3MBTL1 | |
| SCHEMBL26032149 | 0.67 | POLB (0.48) | ALDH1A1POLBTDP1GAAHTT | |
| SCHEMBL11184627 | 0.67 | POLB (0.48) | ALDH1A1HPGDPOLBGAA | |
| SCHEMBL19527666 | 0.67 | POLB (0.39) | ALDH1A1HPGDPOLBTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |