Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10362638 | 0.91 | TACR1 (0.57) | TACR1CFDATM | |
| SCHEMBL10363304 | 0.89 | TACR1 (0.52) | TACR1ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL10748595 | 0.88 | TACR1 (0.64) | TACR1CMA1 | |
| SCHEMBL10362476 | 0.81 | TACR1 (0.53) | TACR1CFDATM | |
| SCHEMBL10362594 | 0.81 | TACR1 (0.67) | TACR1ATM | |
| SCHEMBL10362832 | 0.80 | TACR1 (0.53) | TACR1ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL6354335 | 0.79 | PSMB9 (0.51) | ITGB1ITGA4 | |
| SCHEMBL10364533 | 0.79 | ITGB3 (0.58) | TACR1ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL10748217 | 0.78 | TACR1 (0.51) | TACR1ATM | |
| SCHEMBL3812839 | 0.74 | OPRM1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |