Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364282 | 1.00 | NPC1 (0.36) | NPC1RAB9APKMNPSR1EPHX1 | |
| SCHEMBL10365824 | 0.74 | KDM4E (0.52) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL9363777 | 0.72 | NPC1 (0.49) | NPC1RAB9APKMNPSR1EPHX1 | |
| SCHEMBL9368918 | 0.71 | ALDH1A1 (0.47) | NPC1RAB9APKMNPSR1EPHX1 | |
| SCHEMBL9367333 | 0.70 | ALDH1A1 (0.47) | NPC1RAB9APKMNPSR1EPHX1 | |
| SCHEMBL9368889 | 0.70 | ALDH1A1 (0.46) | NPC1RAB9APKMNPSR1EPHX1 | |
| SCHEMBL10516805 | 0.68 | AHCY (0.40) | — | |
| SCHEMBL9183520 | 0.64 | ACHE (0.41) | NPC1RAB9APKMNPSR1EPHX1 | |
| SCHEMBL13320557 | 0.64 | KDM4E (0.55) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL14160512 | 0.64 | KDM4E (0.55) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212956-B1 | GUANINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4857531-A | Guanine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-15 | — | — | US | disclosed |