Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.56 |
| ▸ | KMO | O15229 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28404845 | 0.89 | KMO (0.57) | MKNK1MKNK2KMOALDH1A1CYP2A6 | |
| SCHEMBL2811220 | 0.84 | ALDH1A1 (0.48) | MKNK1MKNK2ALDH1A1KDM4ELMNA | |
| SCHEMBL30705023 | 0.81 | MKNK1 (0.56) | MKNK1MKNK2KMOALDH1A1CYP2A6 | |
| SCHEMBL10364611 | 0.81 | MKNK1 (0.56) | MKNK1MKNK2KMOALDH1A1CYP2A6 | |
| SCHEMBL28830427 | 0.81 | KMO (0.53) | MKNK1MKNK2KMOALDH1A1CYP2A6 | |
| SCHEMBL28558289 | 0.80 | MKNK1 (0.50) | MKNK1MKNK2KMOALDH1A1CYP2A6 | |
| SCHEMBL5145882 | 0.79 | KDM4E (0.67) | MKNK1MKNK2KMOALDH1A1CYP2A6 | |
| SCHEMBL18797731 | 0.78 | DHODH (0.55) | MKNK1MKNK2KMOALDH1A1APP | |
| SCHEMBL28790988 | 0.78 | HNF4A (0.56) | MKNK1MKNK2KMOALDH1A1L3MBTL1 | |
| SCHEMBL27585150 | 0.78 | MAPK1 (0.52) | MKNK1MKNK2KMOALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206747-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS, AND A PROCESS FOR PRODUCING THE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| EP-0206747-A2 | 1,4-Dihydropyridine derivatives useful in the treatment of cardiovascular disorders, and a process for producing the derivatives | WARNER-LAMBERT COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |